Neurodegeneration and Molecular Neuropathology

Event Details

Neurodegeneration and Molecular Neuropathology

Time: June 13, 2011 to June 25, 2011
Location: San Quirico d'Orcia, Siena
Street: Palazzo Chigi Zondadari - Piazza Chigi 2
City/Town: San Quirico d'Orcia, Siena, Italy
Website or Map: http://www.nsas.it/neurodegen…
Event Type: course
Organized By: Neuroscience School of Advanced Studies
Latest Activity: Apr 19, 2011

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Event Description

At least two reasons justify an intense research focus on neurodegenerative diseases. First, a  steady increase in the prevalence of age-related diseases including neurodegenerative disorders has paralleled the extension of human life span over the past century. This ongoing phenomenon will soon cause profound economical and social challenges and is already becoming a burden for health-care systems. Second, the mechanisms underlying neurodegeneration remain largely unknown and to date there are no disease-modifying therapies against chronic progressive illnesses such as Alzheimer’s and Parkinson’s diseases. Important new clues have emerged, however, from recent molecular and neuropathological research as well as clinical and population studies. An integrated approach that can bridge these scientific disciplines will likely be key to resolving the quandary of disease pathogenesis and finding effective therapeutic/preventive strategies.

This Course will first examine features of neurodegenerative disorders, especially Alzheimer’s and Parkinson’s diseases, in light of the most recent molecular and neuropathological advances and with particular attention to common aspects of the diseases. It will then focus on the cell biology of neuronal death and the pathophysiology of synaptic connectivity and network activity. State-of-the-art techniques to monitor the development of neuropathology in vivo will be illustrated together with the application of modern imaging technologies in the clinical setting and for experimental purposes. The thematic and structure of the course will encourage cross-reference between fundamental and clinical science with the ultimate goal of identifying future research needs and translational opportunities.

Structured lecture sessions will alternate with informal gatherings, specifically designed to stimulate cross-discipllinary talks, productive cross-fertilization of ideas and the establishment of new research collaborations. Each of the following topics will be extensively analyzed and discussed.

The Neuroscience School of Advanced Studies is the home of residential, intensive Courses, where leading investigators from around the world spend two full weeks discussing upcoming research challenges with a small, highly selected number of participants in the unique atmosphere of the fortifies medieval village of San Quirico d'Orcia, all within the most idyllic Tuscan countryside. 

 

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