Hello all

Although, I am new to this group, but I wish we can start a discussion here on the role of tau in AD, its seems like it plays a dwell role in AD - protective and pro-degenerative, depending on the time course of the disease and its spatial and temporal conformation. How do you think about this.

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Mark Smith and others in our group have written extensively on this topic.  We think tau and Abeta are physiological responses to tissue injury. 

George Perry

Thanks Prof. Perry. But i think new evidence is emerging which implicates nuclear tau as having neuroptotective role - see the paper by a french team - Sultan et al. (2011) : Nuclear Tau, a Key Player in Neuronal DNA Protection. Another study by a chineese group has also implicated tau in neuroprotection. See Li, H. L. et al. 2007. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer’s neurodegeneration. Proc Natl Acad Sci U S A. 104(9):3591-6. Thus, it seems like at the early stage, tau is neuroprotective, according to this studies.


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