Scientists at the Univ of California, Irvine have shown that TGF-a can provide almost 99% recovery when administered directly into the brain in rats; 70% improvement when given intranasally.
Worth trying in stroke patients....
1. Guerra-Crespo, M, Gleason, D., Sistos, A., and Fallon, J.H. (2009) Intranasal Administration of PEGylated Transforming Growth Factor-alpha Improves Behavioral Deficits in a Chronic Stroke Model. Journal of Stroke and Cerebrovascular Diseases. In press.
2. Guerra-Crespo, M, D. Gleason, A. Sistos, T.Toosky, I. Solaroglu, J.H. Zhang, P.J. Bryant and Fallon J.H.(2009) Transforming Growth Factor-alpha Induces Neurogenesis and Behavioral Improvement in a Chronic Stroke Model. Neuroscience (in press)